Canine airway responses to acetylcholine, prostaglandin F2alpha, histamine, and serotonin after chronic antigen exposure.

@article{Krell1976CanineAR,
  title={Canine airway responses to acetylcholine, prostaglandin F2alpha, histamine, and serotonin after chronic antigen exposure.},
  author={Robert D. Krell and Lawrence William Chakrin and P Christian and E. Giannone and J. McCoy and Ruth R. Osborn},
  journal={The Journal of allergy and clinical immunology},
  year={1976},
  volume={58 6},
  pages={
          664-75
        }
}

INVESTIGATION OF THE ROLE OF HISTAMINE IN ANTIGEN‐INDUCED BRONCHOCONSTRICTION IN THE ASCARIS‐HYPERSENSITIVE DOG

  • R. Krell
  • Medicine, Biology
    British journal of pharmacology
  • 1978
It is concluded that histamine may not play a major role in mediating the acute antigen‐induced bronchoconstriction in the ascaris‐hypersensitive dog.

Changes in airway responsiveness and β‐ and α‐adrenergic receptors in the lungs of guinea pigs with experimental asthma

It is concluded that the exaggerated airway responsiveness 24 h after allergen challenge is in part due to a decrease in the density of P‐adrenergic receptors.

AN AIRWAY HYPERRESPONSIVENESSMODEL IN RAT ALLERGIC ASTHMA

It is indicated that a model airway hyperresponsiveness was established in rats with allergic asthma, and that the chemical mediators involved in the response might be leukotrienes, thromboxane Az and PAF.

Responsiveness of isolated tracheal smooth muscle in a canine model of asthma

The results indicate that the in vitro pharmacological responsiveness of the trachealis muscle can be correlated with the in vivo responsiveness of these animals to Ascaris suum aerosol bronchial provocation.

Autonomic and autacoid activity in antigen-sensitized and control ovine pulmonary vein and artery.

It is suggested that antigenic sensitization exaggerates the pathological state by causing a decrease in spasmolytic activity with a parallel increase in spasmsogenic activity.

Effects of prolonged repeated exposure to ovalbumin in sensitized brown Norway rats.

AHR, present after single or 3-wk repeated exposure, disappears by 8 wk of continuous allergen exposure, and both the enhancement and suppression of AHR may be linked to OA-induced immune and inflammatory mechanisms.

Canine models of asthma and COPD.

  • R. Chapman
  • Biology
    Pulmonary pharmacology & therapeutics
  • 2008

Pharmacologic characterization of isolated canine bronchial smooth muscle.

  • R. Krell
  • Biology, Chemistry
    European journal of pharmacology
  • 1978

References

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Effects of inhaled prostaglandins E1, E2, and F2alpha on the airway resistance of healthy and asthmatic man.

It was concluded that both PGE1 and PGF2 were highly irritant to inhale and made them unsuitable for therapeutic use, and no correlation could be drawn between increased sensitivity and age, type of asthma, or treatment.

The effect of cholinergic agents on a canine model of allergic asthma.

Histamine release during antigen inhalation in experimental asthma in dogs.

The close correlation between arterial histamine concentration and Rrs, the qualitatively similar response to antigen and 48/80 aerosols, and the inhibition of theresponse to antigen when histamine was depleted completely from the lung tissues suggests that chemical mediators are critically important in antigen-induced airway reactions.

RESPONSE OF RAT LUNG TO HUMORAL MEDIATORS OF ANAPHYLAXIS AND ITS MODIFICATION BY DRUGS AND SENSITIZATION

  • M. Church
  • Biology, Medicine
    British journal of pharmacology
  • 1975
Bradykinin was less active in the rat than in the guinea‐pig and its effects were not antagonized by anti‐inflammatory analgesic drugs and Sensitization with Nippostrongylus brasiliensis did not increase the rat lung to the effects of mediators.

The relationship of histamine and 5‐hydroxytryptamine to anaphylactic shock in different species

The effect on the anaphylactic reaction of depletion of tissue histamine and 5-HT and of specific antagonists of these substances was determined and the amine release from tissues was studied in the rat as well as in the guinea-pig, rabbit and dog.

Role of atropine in antagonizing the effect of 5-hydroxytryptamine (5-HT) on bronchial and pulmonary vascular systems.

5-HT induced bronchoconstriction reflexly, whereas the mode of 5-HT action on the pulmonary vascular system is not due to a reflex involving vagal pathways, and the cause of the different blood gas changes is discussed.

An in vitro model of canine immediate-type hypersensitivity reactions.

It is concluded that fragmented canine lung is a useful model for study of immediate-type hypersensitivity reactions.