Canine Pseudopregnancy: A Review

  title={Canine Pseudopregnancy: A Review},
  author={Arulkumar Thangamani and Manda Srinivas and Borra Chandra Prasad and K. Anusha and K. Sadasiva Rao},
  journal={Journal of Veterinary Science and Technology},
Canine pseudopregnancy is a normal physiological syndrome that occurs in female dogs in their diestrual phase of estrous cycle. It simulates the peri and post-whelping signs that includes nesting, increase in weight and enlargement of mammary gland, lactation and mothering behavior on toys, shoes, puppies of other bitches. Decreased levels of progesterone, meanwhile raised levels of prolactin predispose the bitches to pseudopregnancy. It is a self-limiting clinical condition; however, anti… 

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A Case of Pseudopregnancy in a Bitch
A case of pseudopregnacy was presented to Veterinary Teaching Hospital, Michael Okpara University of Agriculture Umudike, Nigeria and on clinical examination it was observed that bitch had enlarged mammary glands and milk secretion, and physiological parameters were found to be within the normal range.
Use of pyridoxine hydrochloride in the interruption of lactation in female dogs with pseudopregnancy
Vitamin B6 (50mg/kg) has shown to be a safe and economically viable alternative for lactation interruption in female dogs with pseudopregnancy, and was equally efficient in lactation suppression during the investigated period.
Relationship between clinical signs and hormonal analytical findings in bitches with lactatio sine graviditate.
The study indicates that the administration of Prolactin inhibitors alone is not indicated in all cases of lactatio sine graviditate and that the timepoint of onset of the clinically relevant symptoms and the current prolactin level should be taken into account in the treatment of affected bitches.
Revisiting canine pseudocyesis.


A review of canine pseudocyesis.
Individual differences in sensitivity to PRL as well as the existence of molecular variants of canine PRL with different bioactivity versus immunoreactivity ratios may help clarify the aetiopathology of PSC.
Dioestrous ovariectomy: a model to study the role of progesterone in the onset of canine pseudopregnancy.
Only in bitches predisposed to pseudopregnancy would an abrupt decrease in progesterone concentrations induce a substantial increase in prolactin concentrations, which in turn would trigger the typical signs of pseudop pregnancy.
Treatment of pseudopregnancy in the bitch with cabergoline, an ergoline derivative
Cabergoline, a new prolactin inhibitor, was evaluated clinically in 143 bitches with pseudopregnancy and, or, false lactation, 14 cases of lactation after ovariohysterectomy for the removal of dead
On the Post-OEstrous Changes Occurring in the Generative Organs and Mammary Glands of the Non-Pregnant Dog
It has been shown that ovulation normally takes place during œstrus at or near the termination of the sanguineous discharge which characterises the pro-œstrum.
Effect and mechanisms of the anti-prolactin drug cabergoline on pseudopregnancy in the bitch.
A potent anti-prolactin drug, cabergoline, administered orally for five days, was clinically successful in treating three different clinical manifestations of pseudopregnancy in referred bitches, suggesting that the drug may have a direct effect on the tissues as well as in most cases reducing the plasma prolactin concentrations.
Pseudopregnancy in the bitch: the current view on aetiology and treatment
Review of the literature shows that there is no evidence to support the theory that pseudopregnancy is caused by excess or persistent progesterone production, and the condition is closely related to prolactin release from the pituitary gland, and can be treated using a prolactIn inhibiting drug, bromocriptine.
A study of the aetiology of pseudopregnancy in the bitch and the effect of cabergoline therapy
Thirty-two permanently pseudopregnant bitches were treated with the anti-prolactin drug cabergoline, and the rate of success was markedly better than in similar cases treated with reproductive steroids.
[The treatment of pseudopregnancy in the bitch with prolactin inhibitors metergoline and bromocriptine].
It can be deduced from the results presented herein that prolactin is essential for maintaining the pseudogravidity, but keeping up the lactation process--especially galactopoiesis--can probably not be ascribed solely to prol actin.
Acute phase proteins in canine pregnancy (Canis familiaris).
An acute phase response has been identified during mid-gestation in bitches by determination of the serum C-reactive protein (CRP) concentration and no increase in CRP was observed in the serum of two bitches that were not mated following oestrus, but one bitch was diagnosed as pregnant by palpation but did not produce a litter.