Canine ACL fibroblast integrin expression and cell alignment in response to cyclic tensile strain in three-dimensional collagen gels.

@article{Henshaw2006CanineAF,
  title={Canine ACL fibroblast integrin expression and cell alignment in response to cyclic tensile strain in three-dimensional collagen gels.},
  author={DenisL. Henshaw and Erik T. Attia and M. Krishna Bhargava and Jo Ann Hannafin},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2006},
  volume={24 3},
  pages={
          481-90
        }
}
Tissue-engineered ligament substitutes have the potential to become an alternative graft source for ligament reconstruction. If this approach is to become viable, one must first understand and define the mechanisms responsible for creation, maintenance, and remodeling of the native anterior cruciate ligament. It is well accepted that mechanical load alters fibroblast phenotypic expression in a variety of cell sources; however, the mechanosensitive pathways responsible for alteration in matrix… CONTINUE READING
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