Candidiasis in Neutropenic Dogs: Tissue Burden of Infection and Granulocyte Transfusion Effects

Abstract

Neutropenic dogs with systemic candidiasis were studied to establish quantitative relationships between tissue burdens of microorganisms and the kinetics of transfused granulocytes. Three groups of dogs rendered neutropenic by chemotherapy were evaluated. Group I consisted of 8 control dogs that were not challenged with Candida albicans; group II. 6 dogs challenged with 1 0#{176} C. albicans; group III. 7 dogs challenged with 1 0 C. albicans. Granulecytes obtained from random donors were transfused 24 and 48 hr after fungal challenge in groups II and Ill and at comparable times in noninfected controls. Serial granulecyte counts obtained following each transfusion were compared for 1 -hr increments and half-time disappearance (T’/2). At autopsy, 24 hr following the last transfusion. tissues were quantitatively assayed for C. albicans.

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Cite this paper

@inproceedings{Chow2005CandidiasisIN, title={Candidiasis in Neutropenic Dogs: Tissue Burden of Infection and Granulocyte Transfusion Effects}, author={Herbert S. Chow and Suleyman C. Sarpel and Robert Epstein}, year={2005} }