Candidate states of Helicobacter pylori's genome-scale metabolic network upon application of "loop law" thermodynamic constraints.

@article{Price2006CandidateSO,
  title={Candidate states of Helicobacter pylori's genome-scale metabolic network upon application of "loop law" thermodynamic constraints.},
  author={Nathan D. Price and Ines Thiele and Bernhard O. Palsson},
  journal={Biophysical journal},
  year={2006},
  volume={90 11},
  pages={3919-28}
}
Constraint-based modeling has proven to be a useful tool in the analysis of biochemical networks. To date, most studies in this field have focused on the use of linear constraints, resulting from mass balance and capacity constraints, which lead to the definition of convex solution spaces. One additional constraint arising out of thermodynamics is known as the "loop law" for reaction fluxes, which states that the net flux around a closed biochemical loop must be zero because no net… CONTINUE READING

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