Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-κB

@article{Wulczyn1992CandidatePB,
  title={Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-κB},
  author={F Gregory Wulczyn and Michael Naumann and Claus Scheidereit},
  journal={Nature},
  year={1992},
  volume={358},
  pages={597-599}
}
THE NF-κB subunits pSO and p65 and the product of the rel proto-oncogene are members of a growing class of transcription factors with a unique DNA-binding and dimerization domain1–13. Nuclear transfer of each of these factors is controlled by cytoplasmic inhibitors, and regulated by specific stimuli. The inhibitors 1κB-α and -β and pp40 recognize either p65 or the c-rel protein14–16. We show here that the proto-oncogene bcl-3, believed to be involved in certain human B-cell leukaemias17… CONTINUE READING
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