• DOI:10.1016/j.urology.2010.11.046
Corpus ID: 46623581

Candidate molecule for premature ejaculation, DA-8031: in vivo and in vitro characterization of DA-8031.

@article{Jeon2011CandidateMF,
  title={Candidate molecule for premature ejaculation, DA-8031: in vivo and in vitro characterization of DA-8031.},
  author={Hyung-Jun Jeon and H. Kim and Chan-Ho Lee and Young-gun Lee and Seol-Min Choi and Yong-Sung Sohn and Chang-Yong Shin and J. Kim and Hyun-Joo Shim and Kyung-Koo Kang and Byoung-Ok Ahn and S. Kim},
  journal={Urology},
  year={2011},
  volume={77 4},
  pages={
          1006.e17-21
        }
}

Hyung-Jun Jeon, H. Kim, +9 authors S. Kim

Published 2011

Medicine

Urology

OBJECTIVES To evaluate the efficacy of DA-8031 against premature ejaculation, we performed in vitro and in vivo pharmacologic studies. METHODS We used a monoamine transporter binding affinity assay, receptor binding affinity assay, monoamine reuptake inhibition assay, and serotonin uptake inhibition assay in platelets and chemically induced ejaculation models in rats. RESULTS The present study reports on the pharmacologic profile of the putative antipremature ejaculation drug, DA-8031. DA… CONTINUE READING

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