Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice

@article{Liu2006CandidateLT,
  title={Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice},
  author={Pengyuan Y Liu and Yian Wang and Haris G. Vikis and Anna Maciąg and Daolong Wang and Yan Lu and Yan Liu and Ming You},
  journal={Nature Genetics},
  year={2006},
  volume={38},
  pages={888-895}
}
We performed a whole-genome association analysis of lung tumor susceptibility using dense SNP maps (∼1 SNP per 20 kb) in inbred mice. We reproduced the pulmonary adenoma susceptibility 1 (Pas1) locus identified in previous linkage studies and further narrowed this quantitative trait locus (QTL) to a region of less than 0.5 Mb in which at least two genes, Kras2 (Kirsten rat sarcoma oncogene 2) and Casc1 (cancer susceptibility candidate 1; also known as Las1), are strong candidates. Casc1… CONTINUE READING

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