Candidate genes for the hypoxic tumor phenotype.

  title={Candidate genes for the hypoxic tumor phenotype.},
  author={Albert C. Koong and Nicholas C. Denko and Karen M. Hudson and Cornelia Schindler and Lillian Marie Swiersz and Cameron J. Koch and Sydney M Evans and Hani Ibrahim and Quang Trong Le and David James Terris and Amato J. Giaccia},
  journal={Cancer research},
  volume={60 4},
In this study, we have analyzed changes induced by hypoxia at the transcriptional level of genes that could be responsible for a more aggressive phenotype. Using a series of DNA array membranes, we identified a group of hypoxia-induced genes that included plasminogen activator inhibitor-1 (PAI-1), insulin-like growth factor-binding protein 3 (IGFBP-3), endothelin-2, low-density lipoprotein receptor-related protein (LRP), BCL2-interacting killer (BIK), migration-inhibitory factor (MIF), matrix… CONTINUE READING
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