Candidate genes and mechanisms for 2-methoxyestradiol-mediated vasoprotection.

  title={Candidate genes and mechanisms for 2-methoxyestradiol-mediated vasoprotection.},
  author={Federica Barchiesi and Eliana Lucchinetti and Michael Zaugg and Omolara O. Ogunshola and Matthew E Wright and Markus Meyer and Marinella Rosselli and Sara A Schaufelberger and Delbert G. Gillespie and Edwin K Jackson and Raghvendra K Dubey},
  volume={56 5},
2-Methoxyestradiol (2-ME; estradiol metabolite) inhibits vascular smooth muscle cell (VSMC) growth and protects against atherosclerosis and vascular injury; however, the mechanisms by which 2-ME induces these actions remain obscure. To assess the impact of 2-ME on biochemical pathways regulating VSMC biology, we used high-density oligonucleotide microarrays to identify differentially expressed genes in cultured human female aortic VSMCs treated with 2-ME acutely (4 hours) or long term (30 hours… CONTINUE READING


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