Candidate gene studies of fibromyalgia: a systematic review and meta-analysis

  title={Candidate gene studies of fibromyalgia: a systematic review and meta-analysis},
  author={Young Ho Lee and Sung Jae Choi and Jong Dae Ji and Gwan Gyu Song},
  journal={Rheumatology International},
  • Y. Lee, S. Choi, G. Song
  • Published 1 February 2012
  • Biology, Medicine
  • Rheumatology International
The aim of this study was to explore whether the candidate gene polymorphisms contribute to fibromyalgia susceptibility. The authors conducted a meta-analysis on associations between serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) S/L allele, catechol-O-methltransferase (COMT) val158Met, and serotonin 2A (5-HT2A) receptor 102T/C polymorphisms and fibromyalgia susceptibility as determined using the following: (1) allele contrast, (2) recessive, (3) dominant models, and (4… 
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Combining genotype frequencies of candidate SNPs in a well-characterised sample of Spanish women with fibromyalgia and healthy non-fibromyalgia women identified associations of the rs841 and rs1799971 GG genotypes with higher risk of Fibromyalgia susceptibility.
Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158Met polymorphism
It is suggested that catechol-O-methyltransferase gene Val158Met polymorphism is positively associated with FMS and play a relevant role in the clinical symptoms of the disease.
The fibromyalgia family study: a genome-wide linkage scan study.
The estimated sibling recurrence risk ratio (λs) observed in this study suggests a strong genetic component of fibromyalgia, and this is the first report of genome-wide suggestive linkage of Fibromyalgia to the chromosome 17p 11.2-q11.2 region.
Exploring Genetic Susceptibility to Fibromyalgia
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Meta-analysis of associations between interleukin-10 polymorphisms and susceptibility to pre-eclampsia.
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  • Y. LeeS. Bae
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New insights into the genetics of fibromyalgia
Recent advances in, and continuing challenges to, the identification of genes contributing to the development of, and symptom severity in, FM are reviewed.


Possible association of fibromyalgia with a polymorphism in the serotonin transporter gene regulatory region.
The results support the notion of altered serotonin metabolism in at least a subgroup of patients with FM, as a higher frequency of the S/S genotype of 5-HTT was found in FM patients compared with healthy controls.
The association between fibromyalgia and polymorphism of monoamine oxidase A and interleukin-4
The result suggests either the genetic linkage between FM and anxiety or that betweenFM and immunologic diseases are weak, and the MAOA 941 position and IL-4 intron3 polymorphisms are not susceptible markers to predict FM.
Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility
The results suggest that the investigated polymorphisms seem not to be the susceptibility factors in etiology of FMS.
Association of T102C polymorphism of the 5-HT2A receptor gene with pyschiatric status in fibromyalgia syndrome
T102C polymorphism of the 5-HT2A receptor gene is not associated with the etiology of FS, and the results indicate that the T/T genotype may be responsible for psychiatric symptoms of FS.
The T102C Polymorphism of the 5-HT2A-Receptor Gene in Fibromyalgia
The results showed a significantly different genotype distribution in FM patients with a decrease in T/T and an increase in both T/C and C/C genotypes as compared to the control population, which suggests that the T102-allele might be involved in the complex circuits of nociception.
Candidate-gene approach in fibromyalgia syndrome: association analysis of the genes encoding substance P receptor, dopamine transporter and alpha1-antitrypsin.
The current candidate-gene approach study failed to identify significant associations between FMS and three genetic markers with hypothesis-driven clinical relevance, suggesting that a genome-wide association study would be a more fruitful approach for further investigation of the genetic basis of FMS.
Significance of catechol-O-methyltransferase gene polymorphism in fibromyalgia syndrome
ComT polymorphism is of potential pharmacological importance regarding individual differences in the metabolism of catechol drugs and may also be involved in the pathogenesis and treatment of FS through adrenergic mechanisms as well as genetic predisposition to FS.
Which genotype of MAO gene that the patients have are likely to be most susceptible to the symptoms of fibromyalgia?
It seems plausible to say that MAOA-dependent metabolism of the biological amines may be partly related to high-activated MAO-A, allele 3, in the occurrence of FS among Turkish population.
The genetics of fibromyalgia syndrome.
Evidence suggests a role for polymorphisms of genes in the serotoninergic, dopaminergic and catecholaminergic systems in the etiopathogenesis of FMS, and these polymorphisms are not specific for FMS and are similarly associated with additional comorbid conditions.
Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients
Sequence variants of the serotonin receptor subunit genes HTR3A and H TR3B indicate no obvious significance in the aetiology of fibromyalgia, yet they represent the basis for future studies on their pharmacogenetic relevance.