Candidate gene studies of ADHD: a meta-analytic review

  title={Candidate gene studies of ADHD: a meta-analytic review},
  author={Ian R Gizer and Courtney A Ficks and Irwin D. Waldman},
  journal={Human Genetics},
Quantitative genetic studies (i.e., twin and adoption studies) suggest that genetic influences contribute substantially to the development of attention deficit hyperactivity disorder (ADHD. [] Key Result Significant associations were identified for several candidate genes including DAT1, DRD4, DRD5, 5HTT, HTR1B, and SNAP25.

Neuropsychological endophenotypes in attention-deficit/hyperactivity disorder: a review of genetic association studies

  • O. KebirR. Joober
  • Psychology, Biology
    European Archives of Psychiatry and Clinical Neuroscience
  • 2011
The results of genetic studies investigating associations between putative susceptibility genes for ADHD and neuropsychological traits relevant for this disorder were reviewed, and the most investigated genes were DRD4, DAT1, COMT, MAOA, and DBH.

The molecular genetic architecture of attention deficit hyperactivity disorder

A state-of-the-art review of the molecular genetics of ADHD incorporating evidence from candidate gene and linkage designs, as well as genome-wide association studies of common single-nucleotide polymorphisms (SNPs) and rare copy number variations (CNVs).

Molecular Genetics of Attention Deficit–Hyperactivity Disorder (ADHD)

Converging lines of evidence and meta analyses of candidate gene studies have identified that polymorphisms within the dopamine receptor genes 4 and 5, the dopamine transporter gene (DAT1), the synaptosome-associated protein gene (SNAP25) and the serotonin receptor gene (5-HTT) are associated with an increased the risk of ADHD.

Biochemical and genetic analyses of childhood attention deficit/hyperactivity disorder

  • E. Caylak
  • Psychology, Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2012
Understanding the biochemistry and genetics of ADHD will allow this disorder to provide a useful addition with other treatment procedures for ADHD.

Case-control genome-wide association study of attention-deficit/hyperactivity disorder.

Integrated Genome-Wide Association Study Findings : Identification of a Neurodevelopmental Netw ork for Attention Deficit Hyperactiv

Converging neurobiological evidence suggests that ADHD involves alterations of catecholaminergic brain circuits, and evidence from family and twin studies shows that ADHD is a highly heritable disorder, and approximately 76% of the phenotypic variance can be explained by genetic factors.

DRD4 and DAT1 in ADHD: Functional neurobiology to pharmacogenetics

Future strategies for genetic studies in ADHD are discussed, highlighting both the pitfalls and possible solutions relating to candidate gene studies, genome-wide studies, defining the phenotype, and statistical approaches.



Candidate gene studies of attention-deficit/hyperactivity disorder.

The relevance and implications of genetic associations with ADHD for clinical practice and future research are discussed.

Molecular genetics of attention deficit hyperactivity disorder.

Molecular Genetics of Attention-Deficit/Hyperactivity Disorder

Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies.

Several methodological issues, including measurement errors, developmental changes in cognitive abilities, sex, psychostimulant effects and presence of comorbid conditions, represent confounding factors and may explain conflicting results.

Dopamine genes and ADHD

The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes

Examining single-nucleotide polymorphisms spanning 51 candidate genes involved in the regulation of neurotransmitter pathways, particularly dopamine, norepinephrine and serotonin pathways, found nominal significance with one or more SNPs in 18 genes, including the two most replicated findings in the literature: DRD4 and DAT1.

Support for association between ADHD and two candidate genes: NET1 and DRD1

  • A. BobbA. Addington J. Rapoport
  • Biology, Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2005
Support is provided for an association between ADHD and polymorphisms in both NET1 and DRD1; polymorphismsIn ten other candidate genes were not associated with ADHD.

Dopaminergic System Genes in ADHD: Toward a Biological Hypothesis

Lack of association of dopamine D4 receptor gene polymorphisms with ADHD subtypes in a population sample of twins.

A significant association of the exon 3 3-repeat allele with a novel talkative/impulsive latent-class-defined subtype of ADHD is found.

Further evidence of association between two NET single-nucleotide polymorphisms with ADHD

This is the first time that identical alleles of NET from different studies were implicated, and thus this report provides further evidence that the NET gene is involved in the etiology of ADHD.