Candidate gene for the chromosome 1 familial Alzheimer's disease locus

@article{LevyLahad1995CandidateGF,
  title={Candidate gene for the chromosome 1 familial Alzheimer's disease locus},
  author={Ephrat Levy-Lahad and Wilma Wasco and Parvoneh Poorkaj and D. M. Romano and Junko Oshima and W P Pettingell and C.E. Yu and P. D. Jondro and SD Schmidt and K. Wang and Et Al.},
  journal={Science},
  year={1995},
  volume={269},
  pages={973 - 977}
}
A candidate gene for the chromosome 1 Alzheimer's disease (AD) locus was identified (STM2). The predicted amino acid sequence for STM2 is homologous to that of the recently cloned chromosome 14 AD gene (S182). A point mutation in STM2, resulting in the substitution of an isoleucine for an asparagine (N141l), was identified in affected people from Volga German AD kindreds. This N141l mutation occurs at an amino acid residue that is conserved in human S182 and in the mouse S182 homolog. The… Expand
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