Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study.

@article{Cook2005CandidateGA,
  title={Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study.},
  author={Lynnette J. Cook and Luk W Ho and Lin Wang and Edith Terrenoire and Carol Brayne and John Grimley Evans and John Henry Xuereb and Nigel J. Cairns and Dragana Turic and Paul Hollingworth and Pamela J Moore and Luke Jehu and Nicola Archer and Sarah E. Walter and Catherine Foy and Amanda J Edmondson and John G. Powell and Simon Lovestone and Julie Williams and David C Rubinsztein},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2005},
  volume={132B 1},
  pages={5-8}
}
Consistent deficits in the cholinergic system are evident in the brains of Alzheimer's Disease (AD) patients, including reductions in the activities of acetylcholine, acetylcholinesterase (AChE), and choline acetyltransferase (ChAT), increased butyrylcholinesterase (BChE) activity, and a selective loss of nicotinic acetylcholine receptors (nAChRs). Accordingly, we have analyzed polymorphisms in the genes encoding AChE, ChAT, BChE, and several of the subunit genes from neuronal nAChRs, for… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Similar Papers

Loading similar papers…