Candidate gene association studies and risk of chronic lymphocytic leukemia: a systematic review and meta-analysis

@article{Sava2014CandidateGA,
  title={Candidate gene association studies and risk of chronic lymphocytic leukemia: a systematic review and meta-analysis},
  author={Georgina P. Sava and Helen E. Speedy and Richard S. Houlston},
  journal={Leukemia \& Lymphoma},
  year={2014},
  volume={55},
  pages={160 - 167}
}
Abstract To evaluate the contribution of association studies of candidate polymorphisms to inherited predisposition to chronic lymphocytic leukemia (CLL), we conducted a systematic review and meta-analysis of published case–control studies. We identified 36 studies which reported on polymorphic variation in 19 genes and CLL risk. Out of the 23 polymorphic variants, significant associations (p < 0.05) were seen in pooled analyses for only four variants: MDR1, rs1045642; LTA, rs2239704; CD38… Expand
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