Candidate autoantigens in multiple sclerosis.

  title={Candidate autoantigens in multiple sclerosis.},
  author={Stephan Schmidt},
  journal={Multiple sclerosis},
  volume={5 3},
Multiple sclerosis is an inflammatory demyelinating CNS disease of putatively autoimmune origin. Novel models of experimental autoimmune encephalomyelitis (EAE) have demonstrated that T cells specific for various myelin and even nonmyelin proteins are potentially encephalitogenic. The encephalitogenic T cell response directed against different CNS antigens not only determines the lesional topography of CNS inflammation but also the composition of the inflammatory infiltrates. The heterogeneity… CONTINUE READING
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