Candidate SNP Markers of Gender-Biased Autoimmune Complications of Monogenic Diseases Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters

@article{Ponomarenko2016CandidateSM,
  title={Candidate SNP Markers of Gender-Biased Autoimmune Complications of Monogenic Diseases Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters},
  author={Mikhail P. Ponomarenko and Olga V. Arkova and D. A. Rasskazov and Petr M. Ponomarenko and Ludmila K. Savinkova and Nikolay A. Kolchanov},
  journal={Frontiers in immunology},
  year={2016},
  volume={7},
  pages={
          130
        }
}
Some variations of human genome [for example, single nucleotide polymorphisms (SNPs)] are markers of hereditary diseases and drug responses. Analysis of them can help to improve treatment. Computer-based analysis of millions of SNPs in the 1000 Genomes project makes a search for SNP markers more targeted. Here, we combined two computer-based approaches: DNA sequence analysis and keyword search in databases. In the binding sites for TATA-binding protein (TBP) in human gene promoters, we found… CONTINUE READING
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