Candidate Human Genetic Polymorphisms and Severe Malaria in a Tanzanian Population

  title={Candidate Human Genetic Polymorphisms and Severe Malaria in a Tanzanian Population},
  author={Alphaxard Manjurano and Taane G. Clark and Behzad Nadjm and George A. Mtove and Hannah Wangai and Nuno Sep{\'u}lveda and Susana G. Campino and Caroline Maxwell and Raimos M. Olomi and Kirk R. Rockett and Anna E. Jeffreys and Eleanor M. Riley and Hugh Reyburn and Christopher J. Drakeley},
  booktitle={PloS one},
Human genetic background strongly influences susceptibility to malaria infection and progression to severe disease and death. Classical genetic studies identified haemoglobinopathies and erythrocyte-associated polymorphisms, as protective against severe disease. High throughput genotyping by mass spectrometry allows multiple single nucleotide polymorphisms (SNPs) to be examined simultaneously. We compared the prevalence of 65 human SNP's, previously associated with altered risk of malaria… CONTINUE READING
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