Candidate Genes for Nonsyndromic Cleft Palate Detected by Exome Sequencing.

@article{Hoebel2017CandidateGF,
  title={Candidate Genes for Nonsyndromic Cleft Palate Detected by Exome Sequencing.},
  author={A K Hoebel and Dmitriy Drichel and Maartje van de Vorst and Anne C B{\"o}hmer and Sugirthan Sivalingam and Nina Ishorst and Johanna Klamt and Lina Goelz and Margrieta A Alblas and Anna Maaser and Kevin Keppler and Alexander Michael Zink and Michael James Dixon and Jill Dixon and Alexander Hemprich and Teresa Kruse and Iris Graf and Anton Dunsche and G{\"u}l Schmidt and Nikolaos Daratsianos and Stefanie Nowak and Khalid Ahmed Aldhorae and Markus M. N{\"o}then and Michael Knapp and Holger Thiele and Christian Gilissen and Heiko M Reutter and Alexander Hoischen and Elisabeth Mangold and Kerstin U. Ludwig},
  journal={Journal of dental research},
  year={2017},
  volume={96 11},
  pages={1314-1321}
}
Nonsyndromic cleft palate only (nsCPO) is a facial malformation that has a livebirth prevalence of 1 in 2,500. Research suggests that the etiology of nsCPO is multifactorial, with a clear genetic component. To date, genome-wide association studies have identified only 1 conclusive common variant for nsCPO, that is, a missense variant in the gene grainyhead-like-3 ( GRHL3). Thus, the underlying genetic causes of nsCPO remain largely unknown. The present study aimed at identifying rare variants… CONTINUE READING