Candidate Gene Studies of a Promising Intermediate Phenotype: Failure to Replicate

@article{Hart2013CandidateGS,
  title={Candidate Gene Studies of a Promising Intermediate Phenotype: Failure to Replicate},
  author={Amy B. Hart and Harriet de Wit and Abraham A Palmer},
  journal={Neuropsychopharmacology},
  year={2013},
  volume={38},
  pages={802-816}
}
Many candidate gene studies use ‘intermediate phenotypes’ instead of disease diagnoses. It has been proposed that intermediate phenotypes have simpler genetic architectures such that individual alleles account for a larger percentage of trait variance. This implies that smaller samples can be used to identify genetic associations. Pharmacogenomic drug challenge studies may be an especially promising class of intermediate phenotype. We previously conducted a series of 12 candidate gene analyses… CONTINUE READING
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