Candidate Gene Studies of a Promising Intermediate Phenotype: Failure to Replicate

  title={Candidate Gene Studies of a Promising Intermediate Phenotype: Failure to Replicate},
  author={Amy B. Hart and Harriet de Wit and Abraham A Palmer},
Many candidate gene studies use ‘intermediate phenotypes’ instead of disease diagnoses. It has been proposed that intermediate phenotypes have simpler genetic architectures such that individual alleles account for a larger percentage of trait variance. This implies that smaller samples can be used to identify genetic associations. Pharmacogenomic drug challenge studies may be an especially promising class of intermediate phenotype. We previously conducted a series of 12 candidate gene analyses… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 56 times over the past 90 days. VIEW TWEETS
23 Citations
64 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 23 extracted citations


Publications referenced by this paper.
Showing 1-10 of 64 references

netic study using healthy volunteers

  • A Hamidovic, A Dlugos, A Skol, AA Palmer, H de Wit
  • Behav Genet
  • 2009
Highly Influential
11 Excerpts

An association study

  • B e1002197. Flanagin, E Cook, H de Wit
  • 2006
Highly Influential
16 Excerpts

Genome - wide association study of damphetamine response in healthy volunteers identifies putative associations , including cadherin 13 ( CDH 13 )

  • JK Hewitt
  • PLoS ONE
  • 2012
Highly Influential
1 Excerpt

Similar Papers

Loading similar papers…