Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia

@article{Vrij2017CandidateCM,
  title={Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia},
  author={F M S de Vrij and Christian G. Bouwkamp and Nilhan Gunhanlar and Guy Shpak and Bas Lendemeijer and Maarouf Baghdadi and Shreekara Gopalakrishna and Mehrnaz Ghazvini and Tracy M. Li and Marialuisa Quadri and Simone Olgiati and Guido J. Breedveld and Michiel Coesmans and Edwin J. Mientjes and Ton de Wit and Frans W. Verheijen and H. Berna Beverloo and Dan S Cohen and Rob M Kok and P. Roberto Bakker and Aviva Nijburg and Annet T. Spijker and P. M. Judith Haffmans and Erik Hoencamp and Veerle Bergink and Jacob A. S. Vorstman and Timothy S. Wu and Loes M Olde Loohuis and Najaf Amin and Carolyn D. Langen and Albert Hofman and Witte J. G. Hoogendijk and Cornelia M van Duijn and M. Arfan Ikram and Meike W. Vernooij and Henning Tiemeier and Andr{\'e} G. Uitterlinden and Ype Elgersma and B. Distel and J Gribnau and Tonya White and Vincenzo Bonifati and Steven A Kushner},
  journal={Molecular Psychiatry},
  year={2017},
  pages={1-15}
}
Schizophrenia is highly heritable, yet its underlying pathophysiology remains largely unknown. Among the most well-replicated findings in neurobiological studies of schizophrenia are deficits in myelination and white matter integrity; however, direct etiological genetic and cellular evidence has thus far been lacking. Here, we implement a family-based approach for genetic discovery in schizophrenia combined with functional analysis using induced pluripotent stem cells (iPSCs). We observed… CONTINUE READING
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