Candida glabrata persistence in mice does not depend on host immunosuppression and is unaffected by fungal amino acid auxotrophy.

@article{Jacobsen2010CandidaGP,
  title={Candida glabrata persistence in mice does not depend on host immunosuppression and is unaffected by fungal amino acid auxotrophy.},
  author={Ilse D Jacobsen and Sascha Brunke and Katja Seider and Tobias Schwarzmueller and Arnaud Firon and Christophe d'Enfert and Karl Kuchler and Bernhard Hube},
  journal={Infection and immunity},
  year={2010},
  volume={78 3},
  pages={1066-77}
}
Candida glabrata has emerged as an important fungal pathogen of humans, causing life-threatening infections in immunocompromised patients. In contrast, mice do not develop disease upon systemic challenge, even with high infection doses. In this study we show that leukopenia, but not treatment with corticosteroids, leads to fungal burdens that are transiently increased over those in immunocompetent mice. However, even immunocompetent mice were not capable of clearing infections within 4 weeks… CONTINUE READING