Candida antarctica lipase B catalysed kinetic resolutions: Substrate structure requirements for the preparation of enantiomerically enriched secondary alcanols

@inproceedings{Orrenius1995CandidaAL,
  title={Candida antarctica lipase B catalysed kinetic resolutions: Substrate structure requirements for the preparation of enantiomerically enriched secondary alcanols},
  author={Christian Orrenius and Niklas {\"O}hrner and Didier Rotticci and Anders Mattson and Karl Hult and Torbj{\"o}rn Norin},
  year={1995}
}
Abstract The lipase B of the Candida antarctica yeast displays high enantioselectivity in transesterification reactions with chiral secondary alcohols in non-aqueous media. This was exploited to resolve a series of racemates structurally related to 2-octanol, namely 3-hydroxy-1-undecyne, 3-hydroxy-1-nonene, 3-nonanol, 1-chloro-2-octanol, 2-methyl-3-nonanol, 2,2-dimethyl-3-nonanol. The substrates were designed to probe the alcohol binding part of the active site of the lipase. The first four… CONTINUE READING

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