Candida albicans utilizes a modified β-oxidation pathway for the degradation of toxic propionyl-CoA.

@article{Otzen2014CandidaAU,
  title={Candida albicans utilizes a modified β-oxidation pathway for the degradation of toxic propionyl-CoA.},
  author={Christian Otzen and Bettina Bardl and Ilse D Jacobsen and Markus Nett and Matthias Brock},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 12},
  pages={8151-69}
}
Propionyl-CoA arises as a metabolic intermediate from the degradation of propionate, odd-chain fatty acids, and some amino acids. Thus, pathways for catabolism of this intermediate have evolved in all kingdoms of life, preventing the accumulation of toxic propionyl-CoA concentrations. Previous studies have shown that fungi generally use the methyl citrate cycle for propionyl-CoA degradation. Here, we show that this is not the case for the pathogenic fungus Candida albicans despite its ability… CONTINUE READING