Candida albicans morphology and dendritic cell subsets determine T helper cell differentiation.

@article{Kashem2015CandidaAM,
  title={Candida albicans morphology and dendritic cell subsets determine T helper cell differentiation.},
  author={Sakeen W. Kashem and Botond Z. Igy{\'a}rt{\'o} and Maryam Gerami-Nejad and Yosuke Kumamoto and J. Al-Ameri Mohammed and Elizabeth S. Jarrett and Rebecca A Drummond and Sandra Zurawski and Gerard Zurawski and Judith Berman and Akiko Iwasaki and Gordon D Brown and Daniel H Kaplan},
  journal={Immunity},
  year={2015},
  volume={42 2},
  pages={356-366}
}
Candida albicans is a dimorphic fungus responsible for chronic mucocutaneous and systemic infections. Mucocutaneous immunity to C. albicans requires T helper 17 (Th17) cell differentiation that is thought to depend on recognition of filamentous C. albicans. Systemic immunity is considered T cell independent. Using a murine skin infection model, we compared T helper cell responses to yeast and filamentous C. albicans. We found that only yeast induced Th17 cell responses through a mechanism that… CONTINUE READING
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