Candida albicans lacking the frataxin homologue: a relevant yeast model for studying the role of frataxin.

@article{Santos2004CandidaAL,
  title={Candida albicans lacking the frataxin homologue: a relevant yeast model for studying the role of frataxin.},
  author={Renata Santos and Nicole Buisson and Simon A. B. Knight and Andrew Dancis and Jean-Michel Camadro and Emmanuel Lesuisse},
  journal={Molecular microbiology},
  year={2004},
  volume={54 2},
  pages={507-19}
}
We cloned the CaYFH1 gene that encodes the yeast frataxin homologue in Candida albicans. CaYFH1 was expressed in Deltayfh1 Saccharomyces cerevisiae cells, where it compensated for all the phenotypes tested except for the lack of cytochromes. Double DeltaCayfh1/DeltaCayfh1 mutant had severe defective growth, accumulated iron in their mitochondria, lacked aconitase and succinate dehydrogenase activity and had defective respiration. The reductive, siderophore and haem uptake systems were… CONTINUE READING
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