Candida albicans cell-type switching and functional plasticity in the mammalian host

@article{Noble2017CandidaAC,
  title={Candida albicans cell-type switching and functional plasticity in the mammalian host},
  author={Suzanne M. Noble and Brittany A. Gianetti and Jessica N. Witchley},
  journal={Nature Reviews Microbiology},
  year={2017},
  volume={15},
  pages={96-108}
}
Candida albicans is a ubiquitous commensal of the mammalian microbiome and the most prevalent fungal pathogen of humans. A cell-type transition between yeast and hyphal morphologies in C. albicans was thought to underlie much of the variation in virulence observed in different host tissues. However, novel yeast-like cell morphotypes, including opaque(a/α), grey and gastrointestinally induced transition (GUT) cell types, were recently reported that exhibit marked differences in vitro and in… CONTINUE READING
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