Candida albicans VAC8 is required for vacuolar inheritance and normal hyphal branching.

@article{Barelle2006CandidaAV,
  title={Candida albicans VAC8 is required for vacuolar inheritance and normal hyphal branching.},
  author={Caroline J Barelle and Mathias L Richard and C. Gaillardin and Neil A R Gow and Alistair J P Brown},
  journal={Eukaryotic cell},
  year={2006},
  volume={5 2},
  pages={
          359-67
        }
}
Hyphal growth is prevalent during most Candida albicans infections. Current cell division models, which are based on cytological analyses of C. albicans, predict that hyphal branching is intimately linked with vacuolar inheritance in this fungus. Here we report the molecular validation of this model, showing that a specific mutation that disrupts vacuolar inheritance also affects hyphal division. The armadillo repeat-containing protein Vac8p plays an important role in vacuolar inheritance in… CONTINUE READING

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