Candida albicans SET1 encodes a histone 3 lysine 4 methyltransferase that contributes to the pathogenesis of invasive candidiasis.

@article{Raman2006CandidaAS,
  title={Candida albicans SET1 encodes a histone 3 lysine 4 methyltransferase that contributes to the pathogenesis of invasive candidiasis.},
  author={Suresh Babu Raman and Minh Hong Nguyen and Zongde Zhang and Shaoji Cheng and Hong Yan Jia and Nghe Weisner and Kenneth A. Iczkowski and Cornelius J. Clancy},
  journal={Molecular microbiology},
  year={2006},
  volume={60 3},
  pages={697-709}
}
Candida albicans causes diverse mucosal and systemic diseases. Although this versatility likely depends upon carefully co-ordinated gene expression, epigenetic regulation in C. albicans remains poorly characterized. Screening a genomic expression library, we identified C. albicans Set1p as an immunogenic protein with homology to a lysine histone methyltransferase of Saccharomyces cerevisiae. In this study, we demonstrated that total immunoglobulin, IgG and IgM titers against a unique Set1p N… CONTINUE READING

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