Candida albicans IRS4 contributes to hyphal formation and virulence after the initial stages of disseminated candidiasis.

@article{Badrane2005CandidaAI,
  title={Candida albicans IRS4 contributes to hyphal formation and virulence after the initial stages of disseminated candidiasis.},
  author={Hassan Badrane and Shaoji Cheng and Minh Hong Nguyen and Hong Yan Jia and Zongde Zhang and Nghe Weisner and Cornelius J. Clancy},
  journal={Microbiology},
  year={2005},
  volume={151 Pt 9},
  pages={2923-31}
}
Candida albicans is a common cause of mucosal and bloodstream infections. As a screening strategy to identify novel candidal virulence factors, sera recovered from HIV-infected patients with active oropharyngeal candidiasis (OPC) were previously used to probe a C. albicans genomic expression library. IRS4 was identified as a gene that encodes an immunogenic protein. In the present study, the presence of IRS4 transcripts was verified within OPC pseudomembranes recovered from patients. Having… CONTINUE READING

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