Candida albicans Hgt1p, a multifunctional evasion molecule: complement inhibitor, CR3 analogue, and human immunodeficiency virus-binding molecule.

@article{LesiakMarkowicz2011CandidaAH,
  title={Candida albicans Hgt1p, a multifunctional evasion molecule: complement inhibitor, CR3 analogue, and human immunodeficiency virus-binding molecule.},
  author={Iwona Lesiak-Markowicz and Georgia Vogl and Tobias Schwarzmueller and Cornelia Speth and Cornelia Lass-Fl{\"o}rl and Manfred Paul Dierich and Karl Kuchler and Reinhard Wuerzner},
  journal={The Journal of infectious diseases},
  year={2011},
  volume={204 5},
  pages={802-9}
}
BACKGROUND The complement system is tightly controlled by several regulators. Two of these, factor H (FH) and C4b-binding protein (C4BP), can be acquired by pathogens conveying resistance to complement attack. The aim of the study was to characterize the FH binding molecule of Candida albicans, a potentially life-threatening yeast. METHODS The gene coding for this molecule was identified by probing an expression library and homozygous deletion mutants of the respective gene were constructed… CONTINUE READING
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