Candida albicans: A molecular revolution built on lessons from budding yeast

  title={Candida albicans: A molecular revolution built on lessons from budding yeast},
  author={Judith Berman and Peter E. Sudbery},
  journal={Nature Reviews Genetics},
Candida albicans is an opportunistic fungal pathogen that is found in the normal gastrointestinal flora of most healthy humans. However, in immunocompromised patients, blood-stream infections often cause death, despite the use of anti-fungal therapies. The recent completion of the C. albicans genome sequence, the availability of whole-genome microarrays and the development of tools for rapid molecular-genetic manipulations of the C. albicans genome are generating an explosion of information… 

Candida albicans: A Model Organism for Studying Fungal Pathogens

The complete genome sequence of this Pathogen is now available and has been extremely useful for the identification of repertoire of genes present in this pathogen and its complete life style will undoubtedly be useful for developing potential antifungal drugs and tackling Candida infections.

Candida albicans pathogenicity mechanisms

This review presents an update on the current understanding of the pathogenicity mechanisms of this important human pathogen and reveals novel virulence mechanisms have recently been discovered.

Genome-wide functional analysis in Candida albicans

ABSTRACT Candida albicans is an important etiological agent of superficial and life-threatening infections in individuals with compromised immune systems. To date, we know of several overlapping

Integration of Metabolism with Virulence in Candida albicans

The genome of the model pathogenic fungus Candida albicans was sequenced, facilitating unbiased genome-wide explorations of its pathobiology and it has become clear that the regulatory networks controlling certain metabolic pathways in C. albican have undergone transcriptional rewiring in comparison with Saccharomyces cerevisiae, reflecting the evolutionary tuning of C.Albicans to mammalian host niches.

Candida albicans-macrophage interactions: genomic and proteomic insights.

The combination of genomics, proteomics and bioinformatics tools is a powerful strategy to better understand the biological situation of the fungus inside macrophages; part of the fungal population is killed while a significantly high percentage survives.

Targeting Candida albicans filamentation for antifungal drug development

ABSTRACT Candida albicans remains the main etiological agent of candidiasis, as this otherwise normal commensal of humans is capable of causing active infection in immune- and medically-compromised

Candida albicans Infection of Caenorhabditis elegans Induces Antifungal Immune Defenses

It is demonstrated that the yeast form of C. albicans establishes an intestinal infection in Caenorhabditis elegans, whereas heat-killed yeast are avirulent and that nematodes selectively mount specific antifungal defenses at the expense of antibacterial responses.

In-silico based designing of inhibitors against thevirulence and filamentation of Candida albicans, a common human pathogen

  • Sonal MishraK. Misra
  • Biology
    2016 International Conference on Bioinformatics and Systems Biology (BSB)
  • 2016
A common ligand is designed which can bind effectively with both transcriptional factors Tec1 and Rfg1 thus inhibiting the serious fungal infections and damages caused by these.



Genetics of Candida albicans.

Although most molecular analysis to data has been with C. albicans, the same methodologies are proving highly effective with other Candida species, seeing increased application to biological questions such as drug resistance, virulence determinants, and the phenomenon of phenotypic variation.

The glyoxylate cycle is required for fungal virulence

Findings in fungi, in conjunction with reports that isocitrate lyase is both upregulated and required for the virulence of Mycobacterium tuberculosis, demonstrate the wide-ranging significance of the glyoxylate cycle in microbial pathogenesis.

Recent developments in molecular genetics of Candida albicans.

This review outlines recent advances in the development of molecular tools for functional analysis in C. albicans and summarizes current knowledge about the genomic and genetic variability of this important human fungal pathogen.

Genomic evidence for a complete sexual cycle in Candida albicans

Analyzing over 500 genes important for sexual differentiation in S. cerevisiae, many homologues of genes that are implicated in the initiation of meiosis, chromosome recombination, and the formation of synaptonemal complexes are found, but others are striking in their absence.

Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1.

Int1 expression in Saccharomyces cerevisiae was sufficient to direct the adhesion of this normally nonadherent yeast to human epithelial cells, and disruption of INT1 in C. albicans suppressed hyphal growth, adhesion to epithelial Cells, and virulence in mice.

Evidence for mating of the "asexual" yeast Candida albicans in a mammalian host.

These observations demonstrated that C. albicans can recombine sexually, and strains that were subtly altered at the mating-type-like (MTL) locus were capable of mating after inoculation into a mammalian host.

Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans.

The C. albicans mating type-like locus contains several genes not seen in other fungal MAT loci, including those encoding proteins similar to poly(A) polymerases, oxysterol binding proteins, and phosphatidylinositol kinases.

Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1.

A hypha-specific surface protein, Hwp1, with similarities to mammalian small proline-rich proteins was shown to serve as a substrate for mammalian transglutaminases, representing a paradigm for microbial adhesion that implicates essential host enzymes.

Pathogenicity of Candida albicans auxotrophic mutants in experimental infections

Observations suggest that new therapeutic agents for Candida infections might be designed based upon the inhibition of biosynthetic pathways that, in some cases, might be absent from the host.

Rfg1, a Protein Related to the Saccharomyces cerevisiae Hypoxic Regulator Rox1, Controls Filamentous Growth and Virulence in Candida albicans

Results demonstrate that a regulatory protein that controls the hypoxic response in S. cerevisiae controls filamentous growth and virulence in C. albicans, raising new and intriguing questions about the evolutionary relationship between these processes.