Candesartan augments ischemia-induced proangiogenic state and results in sustained improvement after stroke.

@article{Kozak2009CandesartanAI,
  title={Candesartan augments ischemia-induced proangiogenic state and results in sustained improvement after stroke.},
  author={Anna Kozak and Adviye Ergul and Azza B El-Remessy and Maribeth H. Johnson and Livia S Machado and Hazem Elewa and Mohammed A. Abdelsaid and Daniel C Wiley and Susan C Fagan},
  journal={Stroke},
  year={2009},
  volume={40 5},
  pages={1870-6}
}
BACKGROUND AND PURPOSE We have shown that acute treatment with candesartan in an experimental model of stroke resulted in vascular protection and improved outcomes at 24 hours poststroke, but the mechanisms are unknown. We now examine effects of candesartan on proangiogenic factors and 7-day outcomes using the same treatment paradigm. METHODS Male Wistar rats underwent 3 hours of middle cerebral artery occlusion followed by reperfusion. A single dose of 1 mg/kg candesartan intravenously was… CONTINUE READING

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