Cancer without disease
@article{Folkman2004CancerWD,
title={Cancer without disease},
author={Judah Folkman and Raghu Kalluri},
journal={Nature},
year={2004},
volume={427},
pages={787-787}
}Do inhibitors of blood-vessel growth found naturally in our bodies defend most of us against progression of cancer to a lethal stage?
517 Citations
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Tumor growth and progression not only depend on properties of the malignant cells but are strongly influenced by the tumor microenvironment. The tumor stroma consists of various cell types such as ...
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To explore whether cervical carcinoma cell‐derived interleukin‐27 (IL‐27) modulates the angiogenesis of vascular endothelial cells, a large number of cells from across the EGFR spectrum are studied.
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Molecular mechanisms that regulate the evolution of resistance in a tumor with particular emphasis on the role of cell cycle are reviewed.
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An additional perspective is proposed, one in which the tumor cells despite the malignant genome could find a microenvironment either within the tumor or as a dormant cell to remain polar and blend into an organized context.
Pro-metastatic tumor-stroma interactions in breast cancer.
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Identifying and understanding pathways of tumor-stroma cross-talk are likely to lead to the development of novel prognostic biomarkers for metastasis and strategies to prevent metastasis at its earliest stages, resulting in improved patient outcomes.
Gene Therapy Targeted at Angiogenesis and Lymphangiogenesis for Cancer Treatment
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- 2007
Inhibition of angiogenesis/lymphangiogenesis using gene therapy is a potentially important strategy to inhibit the growth of primary tumors and to inhibit their metastatic spread.
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