Cancer without disease
@article{Folkman2004CancerWD,
title={Cancer without disease},
author={Judah Folkman and Raghu Kalluri},
journal={Nature},
year={2004},
volume={427},
pages={787-787}
}Do inhibitors of blood-vessel growth found naturally in our bodies defend most of us against progression of cancer to a lethal stage?
521 Citations
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Tumor growth and progression not only depend on properties of the malignant cells but are strongly influenced by the tumor microenvironment. The tumor stroma consists of various cell types such as ...
Antiangiogenic Cancer Therapy
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To explore whether cervical carcinoma cell‐derived interleukin‐27 (IL‐27) modulates the angiogenesis of vascular endothelial cells, a large number of cells from across the EGFR spectrum are studied.
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Leukocytes as paracrine regulators of metastasis and determinants of organ‐specific colonization
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Microenvironmental regulators of mammary gland architecture: the role of matrix metalloproteinase 3 in epithelial invasion and branching morphogenesis
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An additional perspective is proposed, one in which the tumor cells despite the malignant genome could find a microenvironment either within the tumor or as a dormant cell to remain polar and blend into an organized context.
Pro-metastatic tumor-stroma interactions in breast cancer.
- Medicine, BiologyFuture oncology
- 2012
Identifying and understanding pathways of tumor-stroma cross-talk are likely to lead to the development of novel prognostic biomarkers for metastasis and strategies to prevent metastasis at its earliest stages, resulting in improved patient outcomes.
Gene Therapy Targeted at Angiogenesis and Lymphangiogenesis for Cancer Treatment
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- 2007
Inhibition of angiogenesis/lymphangiogenesis using gene therapy is a potentially important strategy to inhibit the growth of primary tumors and to inhibit their metastatic spread.
Cancer Risk Assessment and Cancer Prevention: Promises and Challenges
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- 2008
“Acquired genetic lability permits stepwise selection of variant sublines and underlies tumor progression” ([1][1]).
Despite intense efforts to cure cancers through advances in staging, surgery,…
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