Cancer without disease

  title={Cancer without disease},
  author={Judah Folkman and Raghu Kalluri},
Do inhibitors of blood-vessel growth found naturally in our bodies defend most of us against progression of cancer to a lethal stage? 

Molecular Regulation of Inflammation and Angiogenesis in the Tumor Microenvironment

Tumor growth and progression not only depend on properties of the malignant cells but are strongly influenced by the tumor microenvironment. The tumor stroma consists of various cell types such as ...

Antiangiogenic Cancer Therapy

Antiangiogenic cancer therapy / , Antiangiogenic cancer therapy / , کتابخانه دیجیتال جندی شاپور اهواز

The cross talk between cervical carcinoma cells and vascular endothelial cells mediated by IL‐27 restrains angiogenesis

To explore whether cervical carcinoma cell‐derived interleukin‐27 (IL‐27) modulates the angiogenesis of vascular endothelial cells, a large number of cells from across the EGFR spectrum are studied.

Tissue-Engineered Prostate Cancer Xenografts: A Biomaterials-Based Approach to Study Tumorigenesis and Dormancy Escape

Tissue-Engineered Prostate Cancer Xenografts: A Biomaterials-Based Approach to Study Tumorigenesis and Dormancy Escape

Leukocytes as paracrine regulators of metastasis and determinants of organ‐specific colonization

This review focuses on the multiple aspects of leukocytes and their effector molecules as regulators of the metastatic process.

Microenvironmental regulators of mammary gland architecture: the role of matrix metalloproteinase 3 in epithelial invasion and branching morphogenesis

An additional perspective is proposed, one in which the tumor cells despite the malignant genome could find a microenvironment either within the tumor or as a dormant cell to remain polar and blend into an organized context.

Commensal bacteria modulate the tumor microenvironment.

Pro-metastatic tumor-stroma interactions in breast cancer.

Identifying and understanding pathways of tumor-stroma cross-talk are likely to lead to the development of novel prognostic biomarkers for metastasis and strategies to prevent metastasis at its earliest stages, resulting in improved patient outcomes.

Gene Therapy Targeted at Angiogenesis and Lymphangiogenesis for Cancer Treatment

Inhibition of angiogenesis/lymphangiogenesis using gene therapy is a potentially important strategy to inhibit the growth of primary tumors and to inhibit their metastatic spread.

Cancer Risk Assessment and Cancer Prevention: Promises and Challenges

  • B. Reid
  • Medicine
    Cancer Prevention Research
  • 2008
“Acquired genetic lability permits stepwise selection of variant sublines and underlies tumor progression” ([1][1]). Despite intense efforts to cure cancers through advances in staging, surgery,



Persistence of microscopic human cancers in mice: alterations in the angiogenic balance accompanies loss of tumor dormancy

These results support a model in which loss of dormancy is controlled in part by a switch to an angiogenic phenotype, and may serve as models for investigating the cellular mechanisms controlling dormancy and identifying those factors that promote the loss of balanced proliferation and apoptosis.

Angiogenesis: Basement membranes: structure, assembly and role in tumour angiogenesis

The basement membrane mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment, constituting an extracellular microenvironment sensor for endothelial cells and pericytes.

Advances in diagnostic imaging and overestimations of disease prevalence and the benefits of therapy.

Over the past two decades a vast new armamentarium of diagnostic techniques has revolutionized the practice of medicine and enhanced the physician's potential for understanding disease and treating patients but also create confusion that may ultimately be harmful to patients.