Cancer therapy with chemically modified enzymes. I. Antitumor properties of polyethylene glycol-asparaginase conjugates.

@article{Abuchowski1984CancerTW,
  title={Cancer therapy with chemically modified enzymes. I. Antitumor properties of polyethylene glycol-asparaginase conjugates.},
  author={A Abuchowski and G M Kazo and C R Verhoest and T P van Es and D. Kafkewitz and Marcio Nucci and Anna T. Viau and Frank G. F. Davis},
  journal={Cancer biochemistry biophysics},
  year={1984},
  volume={7 2},
  pages={175-86}
}
The covalent attachment of monomethoxypolyethylene glycol (PEG) to asparaginases from Escherichia coli and Vibrio succinogenes by new coupling methodology produced conjugates that are active, stable, without significant immune response, and with greatly extended plasma half-lives in mice. Therapeutic efficacies were greater for the PEG-asparaginases than for the unmodified asparaginases in mice infected with the L5178Y lymphosarcoma or the 6C3HED tumor. Large single doses of native or modified… CONTINUE READING