Cancer therapy improvement with mesoporous silica nanoparticles combining targeting, drug delivery and PDT.

@article{GaryBobo2012CancerTI,
  title={Cancer therapy improvement with mesoporous silica nanoparticles combining targeting, drug delivery and PDT.},
  author={Magali Gary-Bobo and Ouahiba Hocine and David Brevet and Marie Maynadier and Laurence Raehm and S{\'e}bastien Richeter and Virginie Charasson and Bernard Loock and Alain Mor{\`e}re and Philippe Maillard and Marcel Garcia and Jean-Olivier Durand},
  journal={International journal of pharmaceutics},
  year={2012},
  volume={423 2},
  pages={509-15}
}
The synthesis of mesoporous silica nanoparticles (MSN) covalently encapsulating fluoresceine or a photosensitizer, functionalized with galactose on the surface is described. Confocal microscopy experiments demonstrated that the uptake of galactose-functionalized MSN by colorectal cancer cells was mediated by galactose receptors leading to the accumulation of the nanoparticles in the endosomal and lysosomal compartments. The MSN functionalized with a photosensitizer and galactose were loaded… CONTINUE READING
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