Cancer therapy based on oncogene addiction.

  title={Cancer therapy based on oncogene addiction.},
  author={Frank Mccormick},
  journal={Journal of surgical oncology},
  volume={103 6},
Tumor cells contain multiple mutations, yet they often depend on continued expressed of a single oncoprotein for survival. Targeting these proteins has led to dramatic responses. Unfortunately, patients usually progress, through drug resistance or adaptive resistance through reprogramming of signaling networks. The Ras-MAPK pathway provides examples of… CONTINUE READING