Cancer therapy: Targeting mitochondria and other sub-cellular organelles.

  title={Cancer therapy: Targeting mitochondria and other sub-cellular organelles.},
  author={Obinna C. Ubah and H. Wallace},
  journal={Current pharmaceutical design},
  volume={20 2},
  • Obinna C. Ubah, H. Wallace
  • Published 2014
  • Biology, Medicine
  • Current pharmaceutical design
  • Tumour cell death is required for the clearance of malignant cells and is a vital part of the mechanism of natural tumour suppression. Cancer cells, having acquired multiple deregulated pathways involving several cellular oragenelles, are capable of disrupting these normally finely tuned processes thereby evading both physiological and therapeutic intervention. Although current available data indicate the dependence of successful tumour cell clearance on classical apoptotic pathways (intrinsic… CONTINUE READING
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