Cancer-testis gene expression profiling in esophageal squamous cell carcinoma: identification of specific tumor marker and potential targets for immunotherapy.

@article{Forghanifard2011CancertestisGE,
  title={Cancer-testis gene expression profiling in esophageal squamous cell carcinoma: identification of specific tumor marker and potential targets for immunotherapy.},
  author={Mohammad Mahdi Forghanifard and Mehran Gholamin and Moein Farshchian and Omeed Moaven and Bahram Memar and Mohammad Forghani and Ezzat Dadkhah and Hossein Naseh and Meysam Moghbeli and Reza Raeisossadati and Mohammad R Abbaszadegan},
  journal={Cancer biology & therapy},
  year={2011},
  volume={12 3},
  pages={191-7}
}
Cancer-testis antigens (CTAs) are often specifically expressed in cancer cells and under normal conditions are only considered to be expressed in the germ line cells and the placenta. CTAs are potential targets for cancer immunotherapy and therefore necessitates their expression profiling. The expression profile of LAGE1, MAGE-A4 and NY-ESO1, their possible correlations and interaction, and the clinicopathological associations of each marker were studied. RNA was extracted from fresh… CONTINUE READING

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