Cancer testis antigen expression in primary and recurrent vulvar cancer: association with prognostic factors.

Abstract

Cancer testis tumour associated antigens (C/T-TAAs) were investigated in several gynaecologic and non-gynaecologic neoplasms as possible prognostic markers and targets for immunotherapy. The objective of the present study was to evaluate C/T-TAA expression patterns and prognostic significance in patients affected by vulvar cancer. Melanoma antigen E (MAGE)-A1, MAGE-A4 and NY-ESO-1 expression was determined by immunohistochemistry in paraffin-embedded tissue specimens from 45 primary and 14 recurrent vulvar carcinomas treated with surgery. MAGE-A1, MAGE-A4 and NY-ESO-1 were expressed in 25 (42%), 38 (64%) and 40 (68%) of the 59 samples, respectively. MAGE-A4 was significantly more frequently expressed in tumours with lymph node metastases (p<0.002) and in recurrent tumours (p<0.02). NY-ESO-1 was more highly expressed by moderately or poorly differentiated tumours (p<0.01). This study demonstrates that vulvar cancer frequently expresses C/T-TAAs. Antigen expression correlates with the presence of lymph node metastases and poor tumour differentiation.

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@article{Bellati2007CancerTA, title={Cancer testis antigen expression in primary and recurrent vulvar cancer: association with prognostic factors.}, author={Filippo Bellati and Chiara Napoletano and Elisabetta Tarquini and Innocenza Palaia and Rachele Landi and Natalina Manci and Giulio Cesare Spagnoli and Aurelia Rughetti and Pierluigi Benedetti Panici and Marianna Nuti}, journal={European journal of cancer}, year={2007}, volume={43 17}, pages={2621-7} }