Cancer-testis antigen expression and its epigenetic modulation in acute myeloid leukemia.

  title={Cancer-testis antigen expression and its epigenetic modulation in acute myeloid leukemia.},
  author={Djordje Atanackovic and Tim Luetkens and Benjamin Kloth and Gregor Fuchs and Yanran Cao and York Hildebrandt and Sabrina Meyer and Katrin Bartels and Henrike Reinhard and Nesrine Lajmi and Susanna Hegewisch-Becker and Georgia Schilling and Uwe- Platzbecker and Guido Kobbe and Thomas A. Schr{\"o}der and C Carsten Bokemeyer and Nicolaus Kr{\"o}ger},
  journal={American journal of hematology},
  volume={86 11},
Cancer-testis antigens (CTA) represent attractive targets for tumor immunotherapy. However, a broad picture of CTA expression in acute myeloid leukemia (AML) is missing. CTA expression was analyzed in normal bone marrow (BM) as well as in AML cell lines before and after treatment with demethylating agents and/or histone acetylase inhibitors. Presence of selected CTA with a strictly tumor-restricted expression was then determined in samples of patients with AML before and after demethylating… CONTINUE READING


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