Cancer-targeting siRNA delivery from porous silicon nanoparticles.

@article{Wan2014CancertargetingSD,
  title={Cancer-targeting siRNA delivery from porous silicon nanoparticles.},
  author={Yuan Song Wan and Sinoula Apostolou and Roman Dronov and Bryone J. Kuss and Nicolas H. Voelcker},
  journal={Nanomedicine},
  year={2014},
  volume={9 15},
  pages={
          2309-21
        }
}
AIMS Porous silicon nanoparticles (pSiNPs) with tunable pore size are biocompatible and biodegradable, suggesting that they are suitable biomaterials as vehicles for drug delivery. Loading of small interfering RNA (siRNA) into the pores of pSiNPs can protect siRNA from degradation as well as improve the cellular uptake. We aimed to deliver MRP1 siRNA loaded into pSiNPs to glioblastoma cells, and to demonstrate downregulation of MRP1 at the mRNA and protein levels. METHODS 50-220 nm pSiNPs… CONTINUE READING
BETA

References

Publications referenced by this paper.
SHOWING 1-10 OF 60 REFERENCES

Similar Papers

Loading similar papers…