Cancer syndromes and therapy by stop-codon readthrough.

  title={Cancer syndromes and therapy by stop-codon readthrough.},
  author={Renata Bordeira-Carriço and Ana Paula P{\^e}go and Manuel A. S. Santos and Carla Oliveira},
  journal={Trends in molecular medicine},
  volume={18 11},
Several hereditary cancer syndromes are associated with nonsense mutations that create premature termination codons (PTC). Therapeutic strategies involving readthrough induction partially restore expression of proteins with normal function from nonsense-mutated genes, and small molecules such as aminoglycosides and PTC124 have exhibited promising results for treating patients with cystic fibrosis and Duchenne muscular dystrophy. Transgenic expression of suppressor-tRNAs and depleting… CONTINUE READING
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