Cancer susceptibility of mice with a homozygous deletion in the COOH-terminal domain of the Brca2 gene.

@article{McAllister2002CancerSO,
  title={Cancer susceptibility of mice with a homozygous deletion in the COOH-terminal domain of the Brca2 gene.},
  author={Kimberly Ann McAllister and L. Michelle Bennett and Chris D. Houle and Toni Ward and Jason Malphurs and N. Keith Collins and Carol Cachafeiro and Joseph Haseman and Eugenia H. Goulding and Donna Bunch and Edward M. Eddy and Barbara J. Davis and Roger Wiseman},
  journal={Cancer research},
  year={2002},
  volume={62 4},
  pages={990-4}
}
Inherited mutations of the human BRCA2 gene confer increased risks for developing breast, ovarian, and several other cancers. Unlike previously described Brca2 knockout mice that display predominantly embryonic lethal phenotypes, we developed mice with a homozygous germ-line deletion of Brca2 exon 27 that exhibit a moderate decrease in perinatal viability and are fertile. We deleted this Brca2 COOH-terminal domain because it interacts directly with the Rad51 protein, contains a nuclear… CONTINUE READING
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Knockout mouse models and mammary carcinogenesis

  • Deng, C-X, S. G. Brodie
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  • 2001
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