Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling.

@article{Li2012CancerstimulatedMS,
  title={Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling.},
  author={Hongyan Li and Ferenc Reinhardt and Harvey R. Herschman and Robert A Weinberg},
  journal={Cancer discovery},
  year={2012},
  volume={2 9},
  pages={
          840-55
        }
}
UNLABELLED Mesenchymal cells of the tumor-associated stroma are critical determinants of carcinoma cell behavior. We focus here on interactions of carcinoma cells with mesenchymal stem cells (MSC), which are recruited to the tumor stroma and, once present, are able to influence the phenotype of the carcinoma cells. We find that carcinoma cell-derived interleukin-1 (IL-1) induces prostaglandin E(2) (PGE(2)) secretion by MSCs. The resulting PGE(2) operates in an autocrine manner, cooperating with… CONTINUE READING
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