Cancer stem-like cell properties are regulated by EGFR/AKT/β-catenin signaling and preferentially inhibited by gefitinib in nasopharyngeal carcinoma.

@article{Zhu2013CancerSC,
  title={Cancer stem-like cell properties are regulated by EGFR/AKT/β-catenin signaling and preferentially inhibited by gefitinib in nasopharyngeal carcinoma.},
  author={Miaozhang Zhu and Gong Zhang and Xiao-Bo Miao and Xubin Deng and Yongzhen Wu and Ying Liu and Zhi-Ru Jin and Xi-Qing Li and Qiu-zhen Liu and D Sun and Joseph R Testa and Kai Yao and G H Xiao},
  journal={The FEBS journal},
  year={2013},
  volume={280 9},
  pages={2027-41}
}
We report that the epidermal growth factor receptor (EGFR) pathway plays a critical role in regulating cancer stem-like cells (CSCs) in nasopharyngeal carcinoma (NPC), one of the most common malignant tumors in Southeast Asia. Effects of EGFR on maintaining CSCs are mainly mediated by AKT signaling, and β-catenin is responsible for governing CSC properties in response to EGFR/AKT activation. Significantly, CSCs are enriched by cisplatin and decreased by gefitinib in NPC xenograft models. Upon… CONTINUE READING
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