Cancer stem cells in glioblastoma.

  title={Cancer stem cells in glioblastoma.},
  author={Justin D Lathia and Stephen C Mack and Erin E. Mulkearns-Hubert and Claudia L L Valentim and Jeremy Rich},
  journal={Genes & development},
  volume={29 12},
Tissues with defined cellular hierarchies in development and homeostasis give rise to tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and mimic their origins. Glioblastoma (GBM) is the most prevalent and malignant primary brain tumor and contains self-renewing, tumorigenic cancer stem cells (CSCs) that contribute to tumor initiation and therapeutic resistance. As normal stem and progenitor cells participate in tissue development and repair, these… CONTINUE READING
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