Cancer stem cells in glioblastoma.

@article{Lathia2015CancerSC,
  title={Cancer stem cells in glioblastoma.},
  author={Justin D Lathia and Stephen C Mack and Erin E. Mulkearns-Hubert and Claudia L L Valentim and Jeremy Rich},
  journal={Genes & development},
  year={2015},
  volume={29 12},
  pages={
          1203-17
        }
}
Tissues with defined cellular hierarchies in development and homeostasis give rise to tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and mimic their origins. Glioblastoma (GBM) is the most prevalent and malignant primary brain tumor and contains self-renewing, tumorigenic cancer stem cells (CSCs) that contribute to tumor initiation and therapeutic resistance. As normal stem and progenitor cells participate in tissue development and repair, these… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 320 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 10 times. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 183 extracted citations

320 Citations

05010015020152016201720182019
Citations per Year
Semantic Scholar estimates that this publication has 320 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 120 references

Cancerous stem cells can arise from pediatric brain tumors.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 9 Excerpts
Highly Influenced

Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity.

Proceedings of the National Academy of Sciences of the United States of America • 2015

A randomized trial of bevacizumab for newly diagnosed glioblastoma

MR Gilbert, JS Wefel
N Engl J Med • 2014

Cancer stem cells in gliomas : identifying and understanding the apex cell in cancer ’ s hierarchy

HamerlikP VenereM, RasmussenRD WuQ, +3 authors J Bartek
Glia • 2014