Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models.

@article{Liu2010CancerSC,
  title={Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models.},
  author={Huiping Liu and Manishkumar R Patel and Jennifer A Prescher and Antonia Patsialou and Dalong Qian and Jiahui Lin and Susanna Wen and Ya-Fang Chang and Michael H. Bachmann and Yohei Shimono and Piero Dalerba and Maddalena Adorno and Neethan A. Lobo and Janet Bueno and Frederick M. Dirbas and Sumanta K Goswami and George Somlo and John S Condeelis and Christopher H. Contag and Sanjiv Sam Gambhir and Michael F. Clarke},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 42},
  pages={18115-20}
}
To examine the role of breast cancer stem cells (BCSCs) in metastasis, we generated human-in-mouse breast cancer orthotopic models using patient tumor specimens, labeled with optical reporter fusion genes. These models recapitulate human cancer features not captured with previous models, including spontaneous metastasis in particular, and provide a useful platform for studies of breast tumor initiation and progression. With noninvasive imaging approaches, as few as 10 cells of stably labeled… CONTINUE READING
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