Cancer stem cells are enriched in the side population cells in a mouse model of glioma.

@article{Harris2008CancerSC,
  title={Cancer stem cells are enriched in the side population cells in a mouse model of glioma.},
  author={Molly Ann Harris and Hyuna Yang and Benjamin E Low and J. Mukherjee and Abhijit Guha and Roderick Terry Bronson and Leonard D Shultz and Mark A. Israel and Kyuson Yun},
  journal={Cancer research},
  year={2008},
  volume={68 24},
  pages={
          10051-9
        }
}
The recent identification of cancer stem cells (CSCs) in multiple human cancers provides a new inroad to understanding tumorigenesis at the cellular level. CSCs are defined by their characteristics of self-renewal, multipotentiality, and tumor initiation upon transplantation. By testing for these defining characteristics, we provide evidence for the existence of CSCs in a transgenic mouse model of glioma, S100beta-verbB;Trp53. In this glioma model, CSCs are enriched in the side population (SP… CONTINUE READING

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