Cancer stem cells and self-renewal.

  title={Cancer stem cells and self-renewal.},
  author={Catherine Adell O'Brien and Antonija Kreso and Catriona H. M. Jamieson},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={16 12},
The cancer stem cell (CSC) or cancer-initiating cancer (C-IC) model has garnered considerable attention over the past several years since Dick and colleagues published a seminal report showing that a hierarchy exists among leukemic cells. In more recent years, a similar hierarchical organization, at the apex of which exists the CSC, has been identified in a variety of solid tumors. Human CSCs are defined by their ability to: (i) generate a xenograft that histologically resembles the parent… CONTINUE READING
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